Notes:

• Activated protein C & S will inhibit factors 5 and 8:

  • Thus, inhibiting coagulation.

• Factor 5 leiden mutation:

  • Resistance of factor 5 to be turned off by protein C:

    • Thus, causing thrombosis.

• Anti-thrombin III will inhibit factor 2:

  • Potentiated by heparin.

• Vitamin K deficiency will cause elevated PT and PTT “both”.

• Warfarin stops the extrinsic pathway:

  • You need a “gun” for the “War”!

• Heparin inhibits the intrinsic pathway:

  • Heparin infusion need to be continuous infusion in “long” IV “line”.

• Factors that activate the extrinsic pathway:

  • Collagen

  • Platelets

  • Prekallikren

  • HMW-kininogen

• Factors that activate the intrensic pathway:

  • Tissue factor (thromboplastin).

• Factor 8 deficiency= Hemophilia A.

• Factor 9 deficiency= Hemophilia B.